Use Orb of Transmutation and Orb of Augmentation in regular endgame maps.

It drops Amulets, rings, belts, jewels, and Hubris. Or, you can use Orb of Transmutation and Orb of Augmentation for the chance at extra monsters in higher level maps. It only drops weapons and has a low value. Or, use Orb of Transmutation and Orb of Augmentation on endgame maps to get good mods. You can just open it to maintain clearing map speed. They contain generic loot and have a low value. Strongbox, Ornate Strongbox and Large Strongbox The expected returns are not high enough to invest Orbs of Alchemy or Orbs of Alteration into it. Use Orb of Transmutation and Orb of Augmentation for a chance at additional items. It drops currency that affect quality: Blacksmith’s Whetstone, Armourer’s Scrap, Glassblower’s Bauble, Gemcutter’s Prism, and Cartographer’s Chisel. Notice that the more you invest crafting, the less profit you will have. Craft for (30 to 60)% increased Quantity of Contained Items, Contains (3 to 8) additional Items. Use Orb of Transmutation, Orb of Augmentation, and Orb of Alteration to it. It drops currency that do not affect quality. Buy only in leagues where progression is slow and map drops are scarce.

It may be worth to use Orb of Alchemy and Chaos Orb in very high-level maps.In high tier maps, using Orb of Transmutation, Orb of Augmentation, and Orb of Alteration to them.Corrupted maps can drop Sarficie Fragments, produce higher tier maps, and rare maps with 8 affixes. Use Vaal Orb corrupts low tier Cartographer’s Strongbox is a viable strategy to produce a large number of corrupted maps. Use Orb of Transmutation and Orb of Augmentation in low tier maps for a chance at added maps or +levels.Choose the cheaper one and look for “Contains additional Divination Cards” mods. Use Orb of Alchemy + Chaos Orb or Orb of Alchemy + Orb of Scouring to get desired mods. Generally speaking, it is only recommended to spend money on crafting Diviner’s Strongbox, Cartographer’s Strongbox, and Arcanist’s Strongbox. There are several different kinds of Strongbox to find, each one providing different amounts or kinds of items. Specifically, Strongboxes have mods and, like items, these mods can be changed with the use of currency. Although Strongboxes are not technically items, they do share some special traits in common with many of Path of Exile's items. Unlike ordinary chests, Strongboxes are protected by monsters that must be defeated before the Strongbox will relinquish its treasures. Strongboxes can be found throughout Path of Exile.

Poe arcanist strongbox